LifeGene is a national collaborative project designed to build up a resource for research in all medical disciplines, enabling new and groundbreaking research on the relationships among heredity, environment and lifestyle. The study will include studying several hundred thousand Swedes with the aim of creating new tools to prevent, diagnose and treat our most common diseases. LifeGene will constitute a platform for a myriad of biomedical research projects. Researchers not only in biomedicine and biotechnology but also behavioral and social sciences may benefit from access to LifeGene. By combining a biological perspective with e-epidemiology, LifeGene will open up new possibilities for a greater understanding of the interplay between heredity, lifestyle and the environment as regards to our most common diseases.